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These patients lost an average of 16.6% of their body weight over 68 weeks

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In summary, given that genetic and pharmacologic elevation in O -GlcNAc levels in cultured adipocytes and mouse models is associated with insulin-resistant phenotypes, it is likely that reducing O -GlcNAc levels in adipocytes should reverse the HBP-induced insulin resistance

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Impaired methionine synthesis and hypomethylation in rats exposed to valproate during gestation